The Science of Lapachol

Using exclusive ingredient technology, our clinically proven, evidence-based formulas support the skin's natural repair process.

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HOW LAPACHOL WORKS

Lapachol is the only patented ingredient that targets your skin's DNA repair pathway at the cellular level— inhibiting the CUL4A protein, a ubiquitin ligase which manages cell repair, but can rush the replication process. Lapachol slows down this process, addressing damage at the source.

Three circular illustrated panels with blue text explain skin DNA repair: damaged skin DNA unfolds to repair itself, the body produces proteins to quickly repair DNA, and replication is slowed by Lapachol for more accurate DNA repair.

BEFORE LAPACHOL

Two damaging processes accelerate
skin aging and compromise healing:

1. Cell Replication Errors

Damage and environmental stress lead to uneven tone, texture issues, and accelerated aging.

2. Chronic Inflammation

CUL4A drives cells to replicate faster than they can repair, sustaining inflammation—prolonging redness and delaying recovery.

An infographic-style illustration inside a white circle shows a blue DNA double helix, a blue X chromosome, and dark blue virus-like spheres, with the caption below reading 'CUL4A inaccurately repairs DNA, leading to skin damage'.
A vertical infographic with three illustrated steps explaining skin DNA repair: damaged skin DNA unfolds to repair itself, the body produces proteins to quickly repair DNA, and replication is slowed by more accurate DNA repair.

AFTER LAPACHOL

Lapachol inhibits CUL4A, cutting off
both damaging processes:

✓ Repairs DNA Damage

Lapachol allows your cells to slow down replication to identify and repair damaged DNA.

✓ Resolves Inflammation

Lapachol restores the replication and repair balance, eliminating the cellular stressors that drive inflammation at its source.

A dark blue circular graphic with a light blue DNA double helix and a medical-style cross/screw icon, plus the text below: 'CUL4A is slowed for more accurate DNA repair without skin damage.'.
Two circular infographic panels on a white background explain CUL4A's role in DNA repair. The left panel, on a light gray background, shows blue DNA and virus-like icons with text: 'CUL4A inaccurately repairs DNA, leading to skin damage.

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An infographic-style illustration inside a white circle shows a blue DNA double helix, a blue X chromosome, and dark blue virus-like spheres, with the caption below reading 'CUL4A inaccurately repairs DNA, leading to skin damage'.
A vertical infographic with three illustrated steps explaining skin DNA repair: damaged skin DNA unfolds to repair itself, the body produces proteins to quickly repair DNA, and replication is slowed by more accurate DNA repair.

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A dark blue circular graphic with a light blue DNA double helix and a medical-style cross/screw icon, plus the text below: 'CUL4A is slowed for more accurate DNA repair without skin damage.'.
Two circular infographic panels on a white background explain CUL4A's role in DNA repair. The left panel, on a light gray background, shows blue DNA and virus-like icons with text: 'CUL4A inaccurately repairs DNA, leading to skin damage.

WHAT A BOARD-CERTIFIED DERMATOLOGIST SEES IN THE SCIENCE

Dr. Marisa Garshick, MD, FAAD, on what sets a DNA-level approach apart form conventional skincare.

Most skincare ingredients work at the surface. Dr. Garshick explains why that distinction matters—and what it means to patients when a formula addresses cellular repair at the source rather than managing symptoms at the surface.

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EXPLORE BY CONDITION

POST PROCEDURE RECOVERY

How lapachol accelerates healing after microneedling, laser, chemical peels, and surgery.

SCARS & WOUND HEALING

The DNA repair mechanism behind scar recovery from surgery, burns, acne, and trauma.

REDNESS & ROSACEA

Clinically tested for chronic redness, NRS-tested, proven safe for sensitive skin.

DAILY REPAIR

DNA-level protection for everyday use, anti-aging, UV damage, and environmental stress.

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CLINICAL EVIDENCE

96%

Saw an improvement in skin redness

91%

Noticed a more even skin tone and less discoloration

44%

Reduction in facial redness—measured by dermatologists

0

Adverse effects reported

*According to a peer-reviewed clinical study

The Clinical Efficacy of Lapachol in Facial Redness Reduction
Journal of Cosmetic Dermatology

Before-and-after split comparison of a woman's face showing skin improvement, labeled 'BASELINE' on the left and 'AFTER 8 WEEKS' on the right.

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96%

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91%

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44%

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Before-and-after split comparison of a woman's face showing skin improvement, labeled 'BASELINE' on the left and 'AFTER 8 WEEKS' on the right.